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Spontaneous Activation of Transforming Growth Factor-ß Gene Transcription in Broncho-Alveolar Mononuclear Cells of Individuals with Systemic Autoimmune Diseases with Lung Involvement

Third Department of Internal Medicine, Osaka University School of Medicine, Fukushima-ku, Osaka 553, Japan

S. Kishimoto

Third Department of Internal Medicine, Osaka University School of Medicine, Fukushima-ku, Osaka 553, Japan

The spontaneous elevation of the transcription of the transforming growth factor-ß (TGF-ß) gene in broncho-alveolar mononuclear cells (BMC) of individuals with autoimmune diseases with lung involvement, by nuclear run-on transcription assay, is shown in this study. In quantification analysis of TGF-ß gene transcription, we found more than 10 times the enhanced transcription of the TGF-ß gene in BMC of individuals with autoimmune diseases with involvement, in comparison to normal healthy subjects or patients with bronchial asthma used as controls. Our observation suggests that TGF-ß, a potent mitogen for fibroblasts, may be produced in BMC during an active immune response in individuals with systemic autoimmune diseases with lung involvement, and may be involved in autoimmune-related pathophysiological changes of cytokine networks in lung involvement such as lung fibrosis.

Key Words: Gene transcription • Systemic autoimmune diseases • Transforming growth factor-ß • Pulmonary fibrosis

Lupus, Vol. 1, No. 1, 27-30 (1991)
DOI: 10.1177/096120339100100105


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