This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Krause, I. Articles by Shoenfeld, Y. Search for Related Content PubMed Articles by Krause, I. Articles by Shoenfeld, Y. Social Bookmarking                   What's this?

Distribution of Two Common Idiotypes of Anticardiolipin Antibodies in Sera of Patients with Primary Antiphospholipid Syndrome, Systemic Lupus Erythematosus and Monoclonal Gammopathies

Steinmet'z Research Unit of Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel

J. Cohen

Steinmet'z Research Unit of Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel

M. Blank

Steinmet'z Research Unit of Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel

R. Bakimer

Steinmet'z Research Unit of Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheba, Israel

A. Cartman

Steinmet'z Research Unit of Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel

A. Hohmann

Department of Clinical Immunology, Flinders Medical Center, South Australia

G. Valesini

Clinica Medica I, Universita di Roma, Rome, Italy

R.A. Asherson

Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London, UK

M.A. Khamashta

Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London, UK

G.R.V. Hughes

Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London, UK

Y. Shoenfeld

Steinmet'z Research Unit of Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Israel

The frequency of two common idiotypes of anticardiolipin antibodies (aCL) was determined in sera from three groups of subjects, patients with systemic lupus erythematosus (SLE), with primary antiphospholipid syndrome (PAPS) and with monoclonal gammopathies (MG), as compared to normal population.

The idiotype 1.10, which was derived from a patient with active SLE and antiphospholipid syndrome, was found more frequently among patients with PAPS (10.5%, 10.5% and 22.20% in MG, SLE and PAPS, respectively) than the idiotype H3, which was derived from a human hybridoma monoclonal aCL generated from a healthy subject immunized with tetanus and diphtheria. The latter idiotype was detected in 8.7%, 6.5% and 11.7% of patients with MG, SLE and PAPS, respectively. Incidental findings in this study include a high prevalence of aCL among patients with MG (23%) and a high prevalence of anti-dsDNA antibodies, detected only by a sensitive enzyme-linked immunosorbent assay, among patients with PAPS. Our results indicate that idiotypic diversity exists among aCL derived from different sources. Some of these cross-reactive idiotypes may be more pathogenic than others.

Key Words: Anticardiolipin • SLE Monoclonal gammopathies • Autoantibodies • Autoimmunity • Idiotypes

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J.-C. Piette and P. Cacoub Antiphospholipid Syndrome in the Elderly: Caution Circulation, June 9, 1998; 97(22): 2195 - 2196. [Full Text] [PDF]

				E. Rossi and M. Costa Fish Oil Derivatives as a Prophylaxis of Recurrent Miscarriage Associated with Antiphospholipid Antibodies (APL) : a Pilot Study Lupus, October 1, 1993; 2(5): 319 - 323. [Abstract] [PDF]