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Lupus
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Antiganglioside Antibodies in Patients with Neuropsychiatric Systemic Lupus Erythematosus

Pereira

Department of Rheumatology, University of Sao Paulo, School of Medicine, Sao Paulo, Brasil

Natalino H. Yoshinari

Department of Rheumatology, University of Sao Paulo, School of Medicine, Sao Paulo, Brasil

Ricardo M. De Oliveira

Department of Rheumatology, University of Sao Paulo, School of Medicine, Sao Paulo, Brasil

Wilson Cossermelli

Department of Rheumatology, University of Sao Paulo, School of Medicine, Sao Paulo, Brasil

Antiganglioside antibodies (AGA) were determined in sera and cerebrospinal fluids (CSF) from 50 systemic lupus erythematosus (SLE) patients, and age-matched normal controls. The SLE patients were subdivided according to the type of clinical manifestation into two groups: neuropsychiatric SLE and active SLE without neuropsychiatric manifestation.

The presence of these antibodies showed a significant correlation between IgG AGA in the CSF and IgM AGA in the serum and neuropsychiatric SLE. Fifteen patients had this antibody in the CSF without detectable levels in the serum. No correlation was seen between anti cardiolipin antibodies in the serum or CSF and neuropsychiatric SLE.

The present work suggests that antibodies against gangliosides may be a marker for neuro psychiatric SLE and that intrathecal antibody production can result in the development of this manifestation.

Key Words: Antiganglioside antibodies • Systemic lupus erythematosus • Cerebrospinal fluid • Neuropsychiatric SLE

Lupus, Vol. 1, No. 3, 175-179 (1992)
DOI: 10.1177/096120339200100309
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