This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Folomeev, M. Articles by Alekberova, Z. Search for Related Content PubMed PubMed Citation Articles by Folomeev, M. Articles by Alekberova, Z. Social Bookmarking                         What's this?

Plasma Sex Hormones and Aromatase Activity in Tissues of Patients with Systemic Lupus Erythematosus

Department of Rheumoendocrinology, Institute of Rheumatology, Moscow, Russia

Maxime Dougados

Rheumatology Clinic, Hopital Cochin, Paris

Joelle Beaune

Laboratory of Biochemistry, Hopital Henri Mondor, Creteil

Jean-Clod Kouyoumdjian

Laboratory of Biochemistry, Hopital Henri Mondor, Creteil

Khalil Nahoul

Foundation de Recherche en Hormonologie, Fresnes, France

Bernard Amor

Rheumatology Clinic, Hopital Cochin, Paris

Zemfira Alekberova

Department of Rheumoendocrinology, Institute of Rheumatology, Moscow, Russia

Clinical observations and experimental data suggest that sex hormones influence the develop ment of systemic lupus erythematosus (SLE). An imbalance between androgen and estrogen plasma levels may suggest an abnormality in the aromatase activity involved in estradiol syn thesis. Aromatase activity in skin and subcutaneous tissue and plasma sex-hormone levels (testosterone, androstenedione, estrone, estradiol, dehydrosterone sulfate, cortisol) were measured in 15 SLE patients (nine female, six male) who had never received corticosteroid treatment and in eight (four female, four male) healthy control subjects. There was a tendency toward an increase in aromatase activity in SLE patients when compared to control subjects. Among SLE patients the aromatase activity varied inversely with disease activity. Patients with SLE had decreased androgen and increased estrogen levels. Aromatase activity in SLE patients had significant direct correlation with estrogen levels. These data suggest that abnormal regulation of aromatase activity may partially explain the abnormalities of estrogen synthesis in SLE.

Key Words: SLE • Hormones • Androgens • Estrogens • Aromatase activity

Lupus, Vol. 1, No. 3, 191-195 (1992)
DOI: 10.1177/096120339200100312


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Cutolo, S. Capellino, and R. H. Straub Oestrogens in rheumatic diseases: friend or foe? Rheumatology, June 1, 2008; 47(suppl_3): iii2 - iii5. [Abstract] [Full Text] [PDF]

				A. Tincani, M. Nuzzo, A. Lojacono, M. Cattalini, and A. Meini Review: Contraception in adolescents with systemic lupus erythematosus Lupus, August 1, 2007; 16(8): 600 - 605. [Abstract] [PDF]

				G. Kokeny, M. Godo, E. Nagy, M. Kardos, K. Kotsch, P. Casalis, C. Bodor, L. Rosivall, H-D. Volk, A.C. Zenclussen, et al. Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice Lupus, July 1, 2007; 16(7): 465 - 477. [Abstract] [PDF]

				M Cutolo, A Sulli, and B Seriolo Estrogens, autoimmunity and the heart Lupus, September 1, 2005; 14(9): 675 - 678. [Abstract] [PDF]

				M Cutolo, A Sulli, S Capellino, B Villaggio, P Montagna, B Seriolo, and R H Straub Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity Lupus, September 1, 2004; 13(9): 635 - 638. [Abstract] [PDF]

				C C Mok and C S Lau Pathogenesis of systemic lupus erythematosus J. Clin. Pathol., July 1, 2003; 56(7): 481 - 490. [Abstract] [Full Text] [PDF]

				D Verthelyi, M Petri, M Ylamus, and D M Klinman Disassociation of sex hormone levels and cytokine production in SLE patients Lupus, May 1, 2001; 10(5): 352 - 358. [Abstract] [PDF]

				R. Moncayo and H. E Moncayo A new endocrinological and immunological syndrome in SLE: elevation of human chorionic gonadotropin and of antibodies directed against ovary and endometrium antigens Lupus, February 1, 1995; 4(1): 39 - 45. [Abstract] [PDF]