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I-123 Iofetamine SPECT Scan in Systemic Lupus Erythematosus Patients with Cognitive and Other Minor Neuropsychiatric Symptoms: A Pilot Study

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Elizabeth Waterhouse

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

James S. Nagel

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Neal W. Roberts

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Steven H. Stern

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Patricia Fraser

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Robert Partridge

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Benjamin Murawski

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Shahram Khoshbin

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

B. Leonard Holman

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Peter H. Schur

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Matthew H. Liang

Divisions of Psychiatry and Neurology, Departments of Medicine, Rheumatology and Immunology, and Radiology, Brigham and Women's Hospital, Harvard Medical School, Robert B. Brigham Multipurpose Arthritis Center, Boston, Massachusetts, USA

Accurate diagnosis of central nervous system (CNS) lupus remains difficult, especially when the manifestations are of subtle cognitive and affective changes. This pilot study reports on the use of I-123 iofetamine single photon emission computerized tomography (SPECT) scans in 18 such patients with documented systemic lupus erythematosus. Eight of the 18 scans were abnormal (44%), four in a diffuse bitemporo-parietal pattern previously noted only in Alzheimer's disease, and four with large focal deficits. Neither the existence of the abnormal scan nor the particular pattern of abnormality correlated with the results of other diagnostic tests. These preliminary results raise the possibility that SPECT scans may offer an additional valuable diagnostic instrument in CNS lupus, although further studies are necessary to delineate their precise role.

Key Words: Lupus • SLE • SPECT • Neuropsychiatric • Cognitive

Lupus, Vol. 1, No. 4, 215-219 (1992)
DOI: 10.1177/096120339200100404


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