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Antibodies against Gangliosides in Patients with SLE and Neurological Manifestations

Department of Internal Medicine, Hospital General Vall d'Hebron, Barcelona, Spain

M. Tintore

Unit of Neurological Research, Department of Neurology, Hospital General Vall d'Hebron, Barcelona, Spain

J. Montalban

Unit of Neurological Research, Department of Neurology, Hospital General Vall d'Hebron, Barcelona, Spain

J. Ordi

Department of Internal Medicine, Hospital General Vall d'Hebron, Barcelona, Spain

M. Vilardell

Department of Internal Medicine, Hospital General Vall d'Hebron, Barcelona, Spain

A. Codina

Unit of Neurological Research, Department of Neurology, Hospital General Vall d'Hebron, Barcelona, Spain

Pathogenesis of neuropsychiatric manifestations of systemic lupus erythematosus (SLE) has not been clearly defined, and the search for pathogenic mechanisms has focused on the importance of several autoantibodies. There is increasing evidence that antibodies against gangliosides may have a pathogenic role in some neurological disorders. The aim of the present study was to examine the association between antibodies against gangliosides and neuropsychiatric SLE. We found anti-type II ganglioside antibodies in two out of 32 patients with multiple sclerosis (6.25%) and in 10 out of 60 patients with SLE (16.6%); five of 17 patients with neurological abnormalities also had high levels of these antibodies (29.4%). Five of the 10 patients with SLE and positive antiganglioside antibody assays had only IgM antibodies, three had IgG antibodies and two had both isotypes. By chi-square analysis, the incidence of anti-type II ganglioside antibodies was not significantly higher in patients with symptoms related to the nervous system than in SLE patients without neurological involvement (P > 0.2). No clear correlation was found between antibodies against gangliosides and cardiolipin.

Key Words: Neuropsychiatric Lupus • Demyelination

Lupus, Vol. 1, No. 5, 299-302 (1992)
DOI: 10.1177/096120339200100505


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