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Review: Complement and Lupus: Old Concepts and New Directions

Department of Immunology, King's College Hospital and School of Medicine, Bessemer Road, London SE5 9PJ, UK

Diego Vergani

Department of Immunology, King's College Hospital and School of Medicine, Bessemer Road, London SE5 9PJ, UK

In this review it is our intention to outline briefly the relevance of the complement system in systemic lupus erythematosus. Three main issues will be addressed: the role of complement in handling immune complexes (ICs), the association between complement deficiencies and IC diseases, and the value of measuring complement components and their conversion products in monitoring disease activity.

Key Words: Systemic lupus erythematosus • Rheumatic diseases • Complement • Complement activation

Lupus, Vol. 1, No. 6, 343-349 (1992)
DOI: 10.1177/096120339200100602


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