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Lupus
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Lupus in the family—analysis of a cohort followed from 1978 to 1999

I Giles

Centre for Rheumatology Bloomsbury Rheumatology Unit, Department of Medicine, University College London, London, UK; Centre for Rheumatology, Arthur Stanley House, 40-50 Tottenham Street, London W1P 9PG, UK I.Giles{at}ich.ucl.ac.uk

D Isenberg

Centre for Rheumatology Bloomsbury Rheumatology Unit, Department of Medicine, University College London, London, UK

Familial lupus is recognised but rarely described in mother-daughter case pairs. We describe the prevalence of lupus occurring in the first degree relatives of a cohort of 300 lupus patients under long-term follow-up at a specialised lupus clinic. Three instances of mothers and their daughters who both developed the disease are described in detail to try and ascertain whether there are any particular clinical/serological/genetic factors in common which might explain the phenomenon.

Key Words: familial • SLE • genetics

Lupus, Vol. 10, No. 1, 38-44 (2001)
DOI: 10.1191/096120301676871229
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[Abstract] [PDF]


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