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Prolactin production by immune cells

Research Service, Southern Arizona VA Health Care System, Tucson, Arizona, the Departments of Surgery and Pharmacology, The University of Arizona College of Medicine, Tucson, Arizona, USA; Research Service, Southern Arizona VA Health Care System, 3601 S. 6th Avenue, Tucson, AZ 85723, USAdmontgom{at}dakotacom.net

Prolactin (PRL) is a pituitary hormone and a cytokine that plays an important role in rodent and human immune responses, including autoimmune diseases. However, many cells and tissues other than the pituitary make PRL, including immune cells. Here, we will present the evidence demonstrating PRL synthesis by different subtypes of immune cells from humans, mice and rats, describe the regulation of PRL gene expression in human lymphocytes, and discuss the functions of PRL made by immune cells. Finally, we will present evidence for involvement of immune cell PRL in human autoimmune disease and suggest how it might play a unique immunoregulatory role.

Key Words: prolactin • protein synthesis • gene expression • immune response • autoimmunity • antigen receptors

Lupus, Vol. 10, No. 10, 665-675 (2001)
DOI: 10.1191/096120301717164895


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