This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Matera, L Articles by Galetto, A Search for Related Content PubMed PubMed Citation Articles by Matera, L Articles by Galetto, A Social Bookmarking                         What's this?

Effect of prolactin on the antigen presenting function of monocyte-derived dendritic cells

Department of Internal Medicine, University of Turin, Corso A.M. Dogliotti 14, 10126 Italy lina.matera{at}unito.it

M Mori

Department of Internal Medicine, University of Turin, Turin, Italy

A Galetto

Department of Oncology, Unity of Oncological Surgery, University of Turin, Turin, Italy

Monocyte derived macrophages (Mf) and dendritic cells (DC) play critical roles at the interface between innate and adaptive immunity. Both types of cells can effectively phagocytose exogenous antigens, whereas only DC can process and present them efficiently to antigen-specific T lymphocytes. The hormone PRL is also produced by immune cells and is regarded as a key component of the neuroendocrine–immune loop and a local regulator of lymphocyte response. Its main feature is cooperation with cytokines and hemopoietins. Triggering of monocyte PRL receptors with physiological-to-supraphysiological concentrations of PRL up-regulates the GMCSF receptors, resulting in synergistic PRL-GM-CSF induced maturation of immature (i)DC. Further incubation induces increased antigen-presenting activity at the highest PRL concentrations studied (200 ng/ml). IFN-g release by allogeneic lymphocytes is dependent on T cell-triggered IL-12 release by PRL-preincubated iDC. This, in turn, may be secondary to increased DC expression of CD40 or IFN-g. The permissive action of high PRL concentrations in the antigen presenting process may be of significance in initiation of the response against major histocompatibility complex (MHC)-presented self-antigens and may explain the association of hyperprolactinemia with autoimmune diseases.

Key Words: dendritic cells • monocytes • prolactin • interferon-g-autoimmunity

Lupus, Vol. 10, No. 10, 728-734 (2001)
DOI: 10.1191/096120301717164967


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				Y. Wang, C. T. Chiu, T. Nakamura, A. M. Walker, B. Petridou, M. D. Trousdale, S. F. Hamm-Alvarez, J. E. Schechter, and A. K. Mircheff Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells Am J Physiol Endocrinol Metab, April 1, 2007; 292(4): E1122 - E1134. [Abstract] [Full Text] [PDF]

				L.-Y. Yu-Lee Prolactin Modulation of Immune and Inflammatory Responses Recent Prog. Horm. Res., January 1, 2002; 57(1): 435 - 455. [Abstract] [Full Text] [PDF]

				L.-y. Yu-Lee Stimulation of interferon regulatory factor-1 by prolactin Lupus, October 1, 2001; 10(10): 691 - 699. [Abstract] [PDF]