This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Walker, A M Search for Related Content PubMed PubMed Citation Articles by Walker, A M Social Bookmarking                         What's this?

Unmodified and phosphorylated prolactin and gamma delta T cell development and function

Division of Biomedical Sciences, University of California, Riverside, CA 92521-0121, USA ameae.walker{at}ucr.edu

This manuscript discusses our studies to date concerning the effects of unmodified prolactin (PRL) and phosphorylated PRL on immune function. Most of the discussion refers to effects of changing the ratio of these two forms in maternal PRL on gd T cell development in rat pups in utero, but limited experiments where adult animals have been directly treated are also discussed. The manuscript begins with some general background on gd T cells and the different forms of PRL and then proceeds to a discussion of experimental findings. Results demonstrate that the ratio of unmodified to phosphorylated PRL during rat pregnancy is crucial to normal epidermal gd T cell development in the pup thymus. Elevation of phosphorylated PRL in the dams, by administration of a recombinant molecular mimic of phosphorylated PRL, produces a defect in epidermal gd T cell seeding and subsequent function in the offspring. In contrast, a functional defect is not seen for uterine gd T cells in the offspring, a finding likely reflective of the continued availability of precursors to these cells after the fetal period. Preliminary results from treatment of the NZB/NZW mouse model of lupus with the two forms of PRL suggest opposing effects of unmodified and phosphorylated PRL on one measure of the disease.

Key Words: unmodified prolactin • phosphoprolactin • gamma delta thymocytes • epidermis • uterus

Lupus, Vol. 10, No. 10, 735-741 (2001)
DOI: 10.1191/096120301717164976


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				L.-y. Yu-Lee Stimulation of interferon regulatory factor-1 by prolactin Lupus, October 1, 2001; 10(10): 691 - 699. [Abstract] [PDF]

				R Hooghe, Z Dogusan, N Martens, B Velkeniers, and E L Hooghe-Peters Effects of prolactin on signal transduction and gene expression: possible relevance for systemic lupus erythematosus Lupus, October 1, 2001; 10(10): 719 - 727. [Abstract] [PDF]