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Prolactin in human systemic lupus erythematosus

Rheumatology Department, Hospital de Especialidades, Centro MedicoLa Raza, IMSS Seris y Zaachila s/n, 02990 MexicoCity, Mexico smre{at}infosel.net.mx

O Vera-Lastra

Internal Medicine Department, Hospital de Especialidades, CentroMedicoNacional La Raza, MexicoCity, Mexico

J M Miranda

M Alcala

Rheumatology Department, Hospital de Especialidades, Centro Medico Nacional La Raza, Mexico City, Mexico

J Alvarez-Nemegyci

Rheumatology Department, Centro Medico Nacional ‘El Fenix’ Merida, Yucatan, InstitutoMexicanoDel SeguroSocial, Mexico

In the last decade, evidence has accumulated to support the hypothesis that both mild and moderate elevations of serum prolactin (PRL) participate in the clinical expression and pathogenesis of systemic lupus erythematosus (SLE). Hyperprolactinemia (HPRL) has been found in 20–30% of patients with SLE. HPRL seems to be associated with clinical activity of SLE during pregnancy. Although the relationship between HPRL and active SLE in non-pregnant patients is controversial, recent clinical and experimental studies support the potential role of prolactin (PRL) as a promoter of clinical activity and severity of SLE. Mild elevations of serum PRL secondary to microadenoma could trigger the onset of SLE in a subset of patients.

Elevated PRL and interleukin (IL)-6 have been found in the urine of patients with active lupus nephritis and in cerebrospinal fluid (CSF) of patients with active central nervous system (CNS) SLE. PRL may therefore participate in the pathogenesis of lupus nephritis and cerebritis, and the presence of PRL may reflect an abnormal communication between the immune system and the neuroendocrine system in active SLE. Lymphocytes from patients with active SLE produce increased amounts of PRL, and this extrapituitary PRL may participate in aberrant immune processes in SLE. There is exciting new evidence that HPRL in SLE may be explained by stimulation of pituitary PRL secretion by cytokines. In addition, defects in peptidergic modulators and dopamine metabolism have been described in patients with SLE. The interactions between PRL, cytoquines, autoantibodies and organ involvement suggest that PRL participates in local and generalized immune and inflammatory processes and acts as a bridge between the neuroendocrine and immune systems in SLE. Understanding the interactions between these systems in SLE will help us to understand and treat this important autoimmune disease.

Key Words: prolactin • organ system involvement • systemic lupus erythematosus

Lupus, Vol. 10, No. 10, 748-756 (2001)
DOI: 10.1191/096120301717164994


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