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Anti-prolactin autoantibodies in paediatric systemic lupus erythematosus patients

Autoimmunity Department, Immunology Research Unit, Hospital de Pediatria, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuahutemoc 330, CP 06725 México, D.F., México.

Ma G Quintal

A K Chavez-Rueda

A Leaños-Miranda

Autoimmunity Laboratory, Immunology Research Unit, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, Mexico

R Berron-Peres

Immunology Department, Instituto Nacional de Pediatria,Secretaria de salud,Maxico

V Baca-Ruiz

C Lavalle-Montalvo

Rhumatology Department Of Hospitalde Pediatrtria,Centro Medico Nacional Siglo XXI,IMSS,Maxico.

The aim of this study was to determine the frequency of anti-prolactin autoantibodies and the relationship among anti-prolactin autoantibodies, serum prolactin (PRL) levels and lupus activity in paediatric patients with systemic lupus erythematosus (SLE) using a transversal study. One-hundred and three consecutive paediatric SLE patients were tested for serum anti-PRL autoantibodies and PRL levels. Clinical disease activity was scored using the SLEDAI index. Anti-PRL autoantibodies were measured by means of gel filtration. The frequency of anti-PRL autoantibodies was 6.7% (7=103), on the basis of the amount of immunoreactive PRL eluted in molecular weight fraction corresponding to IgG (150 kDa). No anti-PRL autoantibodies were found in normoprolactinaemic patients. By contrast, 21.8% (7=32) hyperprolactinaemic patients (hPRL) had anti-PRL autoantibodies. There was a correlation between anti-PRL autoantibody and serum levels of PRL (r_s ¹/4 0.98, P ¹/4 0.0001). Lupus activity was present in 64=103(62.1%) patients, without a significant difference in the frequency of anti-PRL autoantibodies when compared to inactive lupus (7.8 vs5.1%, P > 0.05). Higher levels of serum PRL were associated with lupus activity regardless of other variables (39.6% vs 17.9%, P ¹/4 0.05). Patients with anti-PRL autoantibodies had higher levels of serum PRL than those without anti-PRL autoantibody (41.85 vs 17.77 ng/ml, P ¹/4 0.01) and significantly different frequency of hPRL (100 vs 26%, r ¹/4 0.4531, P< 0.001). We have identified a subset of paediatric SLE patients with hPRL and anti-PRL autoantibodies. Anti-PRL autoantibodies were associated with hPRL state and antibody titres correlated positively with serum PRL levels. These data suggest that anti-PRL autoantibodies could be responsible for hPRL in a subset of SLE patients. An increase in serum PRL levels proved to be related to lupus activity, but there was no statistical relationship between anti-PRL autoantibodies and lupus activity.

Key Words: prolactin • anti-prolactin autoantibody • hyperprolactinaemia • disease activity

Lupus, Vol. 10, No. 11, 803-808 (2001)
DOI: 10.1177/096120330101001107


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