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Increased levels of antiphospholipid antibodies in a woman with left atrial myxoma and systemic embolisms

Department of Vascular Diseases, UniversityMedical Centre, Ljubljana, Slovenia; and 2Department of Cardiology, University Medical Centre, Ljubljana, Slovenia

M abovi

University Medical Centre, Department of Vascular Diseases, Riharjeva 24, 1000 Ljubljana, Slovenia; miso.sabovic{at}trnovo.kclj.si

M Koelj

Department of Cardiology, University Medical Centre, Ljubljana, Slovenia

We describe a case of a 45-y-old woman with a left atrial myxoma, mild to moderate constitutional symptoms and systemic embolisms. Increased levels of antiphospholipid antibodies were detected at admission to the hospital and were graduallynormalized after the surgical removal of the tumor. It is known that myxomas have the peculiar ability to induce a systemic inflammatory state with constitutional symptoms, probably mediated by the production of inflammatory mediators in the tumor. This case suggests that myxomas might have also been implicated in the production of antiphospholipid antibodies. Antiphospholipid antibodies could be just a by-product of the systemic inflammatory response. However, theycould also have a role in the thrombosis on the myxoma surface and systemic embolisms.

Key Words: cardiac myxoma • systemic embolisms • antiphospholipid antibodies

Lupus, Vol. 10, No. 11, 815-817 (2001)
DOI: 10.1177/096120330101001109


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