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Systemic lupus erythematosus and B-cell hematologic neoplasm

Comprehensive Cancer Center and Department of Medicine, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY, USA

P H Wiernik

Comprehensive Cancer Center and Department of Medicine, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY, USA; OLM Comprehensive Cancer Center, New York Medical College 600 East 233rd Street, Bronx, NY 10466, USA

The association of systemic lupus erythematosus (SLE) and B-cell malignancy is widely reported in the literature. Here we report nine cases of concurrent of SLE or discoid lupus erythematosus (DLE) and lymphoma or plasma cell disorder. A MEDLINE search was done using the keywords, ‘SLE’ and ‘lymphoma’ and the characteristics of all identified cases were summarized and analyzed, along with data from our own cases. Numerous variants of B-cell malignancies were encountered in these patients. B-cell malignancy occurs after the diagnosis and treatment of SLE in most reported cases, although it may precede SLE, or occur synchronously with it. The age at onset of the B-cell neoplasm in SLE patients is similar to that in the general population. Mortality in patients with both diseases is associated with progressive B-cell neoplasm, sepsis secondary to either disease, or both. B-cell malignancy and SLE seem to run independent clinical courses rather than being affected by each other. The use of immunosuppressive drugs is common in patients with SLE diagnosed prior to B-cell lymphoma, arguing that the effect of immunosuppression on the pathogenesis of lymphoma can not be excluded. Three areas worthy of study regarding the probable mechanisms for the occurrence of SLE and B-cell malignancies are discussed. A tumor suppressor gene PTEN may link the two disorders via a defective apoptosis pathway to eliminate hyperactive B and T cells in SLE. The accumulation of clonally expanded hyperactive B-cells that recognize self-antigens in the lymph nodes of SLE may predispose these B-cells to DNA breaks, facilitating tumorigenesis. Lastly, EBV infection, found to have a high prevalence in SLE patients, may serve as a common etiological factor in both disorders.

Key Words: systemic lupus erythematosus (SLE) • Hodgkin's disease • non-Hodgkin's lymphoma • PTEN • bcl-2 • EBV

Lupus, Vol. 10, No. 12, 841-850 (2001)
DOI: 10.1191/096120301701548481


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