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Lupus
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Anticardiolipin antibodies are not associated with rheumatic heart disease

H Ilarraza

M F Márquez

A Alcocer

Department of Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, México City, Mexico

J L Bañales

A H Nava

Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, México City, Mexico

P A Reyes

Research Division, Instituto Nacional de Cardiología Ignacio Chaávez, México City, Mexico; Research Division. Instituto Nacional de Cardiología I Chávez, J Badiano 1, Sección XVI, Tlalpan, 14080 México D.F., Mexico preyes44{at}yahoo.com

The aim of this study was to examine the prevalence of anticardiolipin antibodies in rheumatic valve heart disease.

Serum samples of 31 consecutive patients with rheumaticheart disease and documented valve involvement, as well assix patients with acute rheumatic fever were tested for IgGanticardiolipin antibodies by a validated ELISA. No anticardiolipin antibodies were found when a cut-off point set at mean 5 s.d. was applied.

We can conclude that anticardiolipin antibodies are notpresent in rheumatic heart disease patients and, as suggested by several observations, these antibodies do not appear to have a pathogenic role in this particular disease.

Key Words: anticardiolipin antibodies • heart valve disease • rheumatic heart disease

Lupus, Vol. 10, No. 12, 873-875 (2001)
DOI: 10.1191/096120301701548526
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