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Therapeutic response and long-term follow-up in a systemic lupus erythematosus patient presenting with Kikuchi's disease

Department of Internal Medicine, Division of Rheumatology, Universidad Central del Caribe School of Medicine, Call Box 60327, Bayamón, PR 00960-6032, USA.

A M Mayor

Department of Internal Medicine, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico

I E Silvestrini

Department of Pathology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico

Kikuchi's disease (KD) can occur in association with systemic lupus erythematosus (SLE). The treatment of concomitant diseases, however, is unclear. We describe a case of a 45-y-old man who presented with generalized histiocytic necrotizing lymphadenitis, fever, malaise and weight loss. Ten months later he also developed arthritis, serositis, anemia, leukopenia and lymphopenia. ANA, anti-Smith, anti-snRNP and anti-Ro antibodies were positive. He responded rapidly and favorably to mid-dose prednisone. Hydroxychloroquine, added 5 months later, allowed tapering down and discontinuation of prednisone treatment. He has remained in complete remission for 5 years.

Key Words: systemic lupus erythematosus • Kikuchi's disease • corticosteroids • hydroxychloroquine

Lupus, Vol. 10, No. 2, 126-128 (2001)
DOI: 10.1191/096120301673275701


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