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Lupus
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Treatment of systemic lupus erythematosus with bromocriptine

S E Walker

Department of Internal Medicine, The University of Missouri-Columbia, Columbia, Missouri, USA

Prolactin, a lactogenic hormone, is a cytokine and an inportant link between the immune and endocrine systems. Prolactin stimulated disease in autoimmune NZB/NZW mice. Treatment of the mice with the prolactin-lowering dopamine agonist, bromocriptine, suppressed anti-DNA and prolonged life spans. These findings have been applied to humans with systemic lupus erythematosus (SLE). An open-label study, a double blind study, and a study comparing bromocriptine to hydroxychloroquine provided evidence that bromocriptine therapy reduced flares and suppressed disease activity in SLE.

Key Words: systemic lupus erythematosus • bromocriptine • prolactin

Lupus, Vol. 10, No. 3, 197-202 (2001)
DOI: 10.1191/096120301666625458
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