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High-dose intravenous immunoglobulins for lupus nephritis — a salvage immunomodulation

Department of Medicine B and the Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel; Research Institute of Rheumatic Diseases, Piestany, Slovak Republic, Israel

J Lukac

Research Institute of Rheumatic Diseases, Piestany, Slovak Republic, Israel

Y Levy

Department of Medicine B and the Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel

J Rovensky

Research Institute of Rheumatic Diseases, Piestany, Slovak Republic, Israel

Y Shoenfeld

Department of Medicine B and the Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel; Department of Medicine B, Sheba Medical Center, Tel Hashomer, 52621, Israel. Tel: +972 3 5302652; Fax: +972 3 5352855,shoenfel{at}post.tau.ac.il

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with a great diversity of clinical manifestations which is difficult to manage. IVIGs represent promising immunoregulatory agents with the ability to control SLE without subsequent predisposition to infectious complications. Despite the implied risk of developing renal failure due to IVIG, considerable beneficial effects on lupus nephritis are reported. In this review, the clinical and adverse effects, and machanism of action, with special emphasis on modulation, of idiotypic network is discussed.

Key Words: IVIG • SLE • lupus nephritis • DNA • anti-idiotypes

Lupus, Vol. 10, No. 3, 209-213 (2001)
DOI: 10.1191/096120301668222237


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