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Antiaggregant and anticoagulant therapy in systemic lupus erythematosus and Hughes' syndrome

Lupus Research Unit, St Thomas' Hospital, London, UK; Service of Internal Medicine, Hospital de Mendaro, Gipuzkoa, Spain

M A Khamashta

Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK106404.2325{at}Compuserve.com

G RV Hughes

Lupus Research Unit, St Thomas' Hospital, London, UK

Antiaggregant and anticoagulant drugs are essential in the management of the manifestations due to antiphospholipid syndrome (APS) in patients with primary Hughes' syndrome or systemic lupus erythematosus. Coumadin derivatives (warfarin and acenocumarol), heparin and aspirin are used for secondary thromboprophylaxis and treatment of recurrent miscarriage. The available evidence for each indication is reviewed in this paper. There is still debate regarding the optimal intensity of oral anticoagulation, the best drug combination for pregnancy failure in APS and the management of asymptomatic patients with antiphospholipid antibodies.

Key Words: antiphospholipid • aspirin • heparin • miscarriage • thrombosis • warfarin

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