Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leiba, A
Right arrow Articles by Shoenfeld, Y
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leiba, A
Right arrow Articles by Shoenfeld, Y
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 10, No. 3, 246-248 (2001)
DOI: 10.1191/096120301674681790

Reviews

Diet and lupus

A Leiba

H Amital

Research Unit of Autoimmune Diseases, Department of Medicine B Chaim Sheba Medical Center, Tel Hashomer, Israel

M E Gershwin

Dept of Rheumatology, Immunology and Allergy, U.C. Davis, CA, USA

Y Shoenfeld

Research Unit of Autoimmune Diseases, Department of Medicine B Chaim Sheba Medical Center, Tel Hashomer, Israel; Department of Medicine B and Research Unit of Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel, Tel: +972 3 5302652; Fax: +972 3 5352855

The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span.

The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammmatory eicosanoids and cytokines.

Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.

Key Words: lupus erythematosus • polyunsaturated fatty acids (PUFAs) • fish oil • linseed oil • autoimmune diseases


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Nutr Clin PractHome page
R. A. Siddiqui, K. A. Harvey, G. P. Zaloga, and W. Stillwell
Modulation of Lipid Rafts by {Omega}-3 Fatty Acids in Inflammation and Cancer: Implications for Use of Lipids During Nutrition Support
Nutr Clin Pract, February 1, 2007; 22(1): 74 - 88.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. J. Auborn, M. Qi, X. J. Yan, S. Teichberg, D. Chen, M. P. Madaio, and N. Chiorazzi
Lifespan Is Prolonged in Autoimmune-Prone (NZB/NZW) F1 Mice Fed a Diet Supplemented with Indole-3-Carbinol
J. Nutr., November 1, 2003; 133(11): 3610 - 3613.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Zeyda, A. B. Szekeres, M. D. Saemann, R. Geyeregger, H. Stockinger, G. J. Zlabinger, W. Waldhausl, and T. M. Stulnig
Suppression of T Cell Signaling by Polyunsaturated Fatty Acids: Selectivity in Inhibition of Mitogen-Activated Protein Kinase and Nuclear Factor Activation
J. Immunol., June 15, 2003; 170(12): 6033 - 6039.
[Abstract] [Full Text] [PDF]