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Atherosclerosis and autoimmunity

The Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK 106404.2325{at}compuserve.com

J George

Department of Medicine B, Research Unit of Autoimmune Diseases, Chaim Sheba Medical Centre, Tel-Hashomer, Israel

M A Khamashta

The Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London, UK

D Harats

Department of Medicine B, Research Unit of Autoimmune Diseases, Chaim Sheba Medical Centre, Tel-Hashomer, Israel

G Hughes

The Lupus Research Unit, Rayne Institute, St Thomas' Hospital, London, UK

Y Shoenfeld

Department of Medicine B, Research Unit of Autoimmune Diseases, Chaim Sheba Medical Centre, Tel-Hashomer, Israel

Novel risk factors for the progression of atherosclerosis such as C-reactive protein (CRP) and adhesion molecules have stimulated much recent interest in the role of inflammation in athero-sclerotic disease. There is also evidence emerging that autoimmunity may have a role in the pathogenesis of atherosclerosis. In this article we explore the evidence for the role of autoimmunity in human atherosclerosis, both in the general population and in the context of the antiphospholipid syndrome. In particular we will focus on several autoantigens, review the evidence for their role in the process of atherosclerosis and the nature of the immune responses.

Key Words: OxLDL • lipoprotein (a) • Hughes' Syndrome • heat shock protein

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