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Osteoporosis in murine systemic lupus erythematosus - a laboratory model

The B Shine Department of Rheumatology, Rambam Medical Center and Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel; Musculoskeletal Research Laboratory, the Rappaport Family Institute for Research in the Medical Sciences and Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel

A Kabala

Musculoskeletal Research Laboratory, the Rappaport Family Institute for Research in the Medical Sciences and Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel

B Raz

E Israeli

Endocrinology Laboratory, Rambam Medical Center, Haifa, Israel

The aim of this study was to assess the skeletal metabolism in a murine model of systemic lupus erythematosus (SLE). MRL/n and MRL/l mice (respectively representing a benign and a malignant form of the disease) were observed from 1.5 to 6.5 months of life. The monthly follow-up included: biochemical and histomorphometrical studies of the femoral bone, serum biochemistry, immunoglobulins and osteocalcin, and histological evaluation of the kidney tissue. The results showed a higher femoral weight (/ 11.5%), calcium (/ 4.4%) and protein bone content (/ 11.4%) and a significantly higher (/ 77%) phosphorus bone content in the MRL =n group; significantly lower (748.9%) bone alkaline phosphatase enzymatic activity, lower bone alkaline/acid phosphatase enzymatic activities ratio (740.8%) and lower (738.4%) serum osteocalcin values in the MRL/l group (which might suggest reduced bone formation in these animals); markedly smaller trabecular bone volume (BV/TV) in the femoral head (736.2%) and femoral neck (739.8%), and smaller cortical and femoral areas in the mid-femoral shaft (738.8% and 738.1% respectively) in the MRL/l group; higher serum immunoglobulins, increased serum blood urea nitrogen (BUN) and creatinine and a higher index of activity in the kidney histology in the MRL/l group, indicating increased activity of the disease in this substrain. The MRL mice, through their two substrains, may serve as a valuable laboratory animal model for study of the skeletal changes in SLE and of the influence of the disease activity on the skeletal metabolism.

Key Words: SLE • mice • bone • osteoporosis

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