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Prevention of autoantibody formation and prolonged survival in New Zealand Black/New Zealand White F1 mice with an ancient Chinese herb, Ganoderma tsugae

Section of Allergy, Immunology and Rheumatology, Department of Medicine, Buddhist Tzuchi Dalin General Hospital, No. 2, Min-Sheng Road, Dalin Town, Chi-Yi, Taiwan, Republic of China

R-H Lin

Institute of Immunology, National Taiwan Medical College, Taiwan, Republic of China

R-S Lai

Department of Medicine, Kaoshung Veterans; Taiwan, Republic of China General Hospital, Taiwan, Republic of China

U-C Kun

S-C Leu

Section of Allergy, Immunology and Rheumatology, Department of Medicine, Tzuchi DaLin General Hospital, Dalin Town, Chi-yi, Taiwan, Republic of China

For centuries, Chinese medicine has regarded Ganoderma, a fungus (Myceteae, Amastigomycota, Basidomycetes, Aphyllophorales, Polyporaceae, Ganoderma) also known as ‘Ling Zhi’ in Mandarin, as a premium remedy for many diseases. Until now, no convincing data regarding its therapeutic effects in vivo on autoimmune diseases have been demonstrated. In this study, a controlled protocol was conducted in which New Zealand Black/White F₁ mice were fed standard chow with prednisolone (0.5 mg/kg/day) or Ganoderma tsugae extract, commencing at 2 months of age. It was found that the F₁ mice responded well to Ling Zhi extract. Ling Zhi improved the survival rate of lupus mice, decreased the amount of proteinuria, decreased serum levels of anti-dsDNA autoantibody, and showed evidence of decreased perivascular and parenchyma mono-nuclear cell infiltration in vital organs.

Key Words: Ganoderma • NZB/NZW F1 mice • herb • fungus • autoantibody

Lupus, Vol. 10, No. 7, 461-465 (2001)
DOI: 10.1191/096120301678416006


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