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FcRIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients

Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea

H K Koh

Division of Rheumatology, Chosun University, Kwangju, Korea

S-S Kim

Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea

W T Chung

Division of Rheumatology, Dong-A University, Pusan, Korea

D W Kim

Division of Rheumatology, Inje University, Pusan, Korea

K P Hong

Division of Rheumatology, Koshin University, Pusan, Korea

G G Song

Division of Rheumatology, Korea University, Seoul, Korea

H K Chang

Division of Rheumatology, Ulsan

J-Y Choe

Division of Rheumatology, Catholic University, Taegu, Korea

S-C Bae

Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea

J E Salmon

Division of Rheumatology, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, USA

D-H Yoo

Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea; Hospital for Rheumatic Diseases, Hanyang University, Seoul 133-792, Korea; dhyoo{at}hanyang.ac.kr

T-Y Kim

Division of Diagnostic Immunology, Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea

S Y Kim

Division of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea

The aim of this study was to determine the distribution of the FcgRIIa and FcgRIIIa polymorphisms and their association with clinical manifestations in Korean lupus patients.

Three hundred SLE (systemic lupus erythematosus) patients (48 male, 252 female) meeting 1982 ACR criteria and 197 Korean disease-free controls were enrolled. Genotyping for FcgRIIa 131 R/H and FcgRIIIa 176 F/V was performed by PCR of genomic DNA using allele-specific primers and the FcgRIIIa genotype was confirmed by direct sequencing of PCR product in some cases.

There was significant skewing in the distribution of the three FcgRIIa genotypes between the SLE and the controls (P=0.002 for R =R131 vs R/H131 and H/H131, OR 2.5 (95% CI 1.4–4.5), but not in FcgRIIIa genotypes. FcgRIIa-R allele was a significant predictor of lupus nephritis, as compared with SLE patients without nephritis (P=0.034 for R131 vs H131, OR 1.4 (95% CI 1.03–1.9)), but proliferative nephritis (WHO class III and IV) was less common in patients with FcgRIIa-R/R131 and in FcgRIIa-R allele. In 300 SLE patients, high binding allele combination H131=V176 was less common in SLE with nephritis than in SLE without nephritis. Hemolytic anemia was less common in R131=F176 allele combination among four FcgRIIa/FcgRIIIa allelic combinations. Male SLE patients showed a higher frequency of renal involvement, serositis, thrombocytopenia, malar rash and discoid rash than female SLE, and male SLE had a higher frequency of FcgRIIa-R/R131 or R131-allele than male controls, but FcgRIIa or FcgRIIIa genotypes had no association with renal involvement in male SLE patients. FcgRIIa-H/H131 showed a higher frequency of hemolytic anemia and less pulmonary complications in male SLE. Female SLE patients showed higher frequency of any hematologic abnormality, lymphopenia, anti-cardiolipin antibody (/) and anti-Ro antibody (/) than male SLE, and had earlier onset of first symptoms. There was no skewing in FcgRIIa or FcgRIIIa genotypes between female SLE and female controls, but FcgRIIa-R131 allele showed skewing between female SLE with nephritis and female SLE without nephritis. The age at onset of thrombocytopenia was earlier in FcgRIIa-R/R131 among three FcgRIIa genotypes, and serositis in FcgRIIIa-F/F176 among three FcgRIIIa genotypes.

FcgRIIa-R131 homozygote was a major predisposing factor to the development of SLE and FcgRIIa-R131 homozygote and R131 allele were a predisposing factor, and H131=V176 was a protective allele combination in lupus nephritis. In contrast to other ethnic patients, in our study cohort, clinical manifestation was different between male and female, and FcgRIIa and FcgRIIIa showed somewhat different clinical associations between the genders.

Key Words: SLE • clinical manifestation • Fcg receptor • polymorphism • gender

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