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Association of b2-glycoprotein I IgG and IgM antibodies with thrombosis and thrombocytopenia

Department of Internal Medicine C, Section of Rheumatology, Odense University Hospital, DK-5000 Odense C, Denmark. a.voss{at}dadlnet.dk

S Jacobsen

Rheumatology Research Unit, Department of Rheumatology, Hvidovre University Hospital, Hvidovre, Denmark

N HH Heegaard

Department of Autoimmunology, Statens Serum Institut, Denmark

Antiphospholipid antibodies (APA) have been known for decades. Their relation to clinical manifestations, primarily thromboses and thrombocytopenia, was recognised in the 1980s. In this clinical study two cohorts of patients, a population-based (84 patients with systemic lupus erythematosus (SLE)) and a hospital-based (87 patients with SLE and 53 with other connective tissue diseases) were investigated for APA and associated clinical manifestations. Anticardiolipin antibodies (ACA) of IgG and IgM classes were found in 13 and 38% of the population-based patients and in 29 and 58% of the hospital-based patients, respectively. The corresponding figures for antibodies against b₂-glycoprotein I (anti-b₂GPI) were 15 and 10% in the population-based patients and 14 and 8% in the hospital-based cohort. Anti-b₂GPI antibodies were always found in association with the corresponding immunoglobulin class of ACA. In both cohorts anti-b₂GPI of the IgG class were associated with arterial/venous occlusion, a result concordant with other studies. A novel finding in both cohorts, however, was an association between thrombocytopenia and IgM anti-b₂GPI.

Key Words: antiphospholipid antibodies • b2-glycoprotein I • antiphospholipid syndrome • thrombosis • thrombocytopenia

Lupus, Vol. 10, No. 8, 533-538 (2001)
DOI: 10.1191/096120301701549651


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