This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lee, Y H Articles by Song, G G Search for Related Content PubMed PubMed Citation Articles by Lee, Y H Articles by Song, G G Social Bookmarking                         What's this?

Polymorphisms of the CTLA-4 exon 1 and promoter gene in systemic lupus erythematosus

Y R Kim

J D Ji

Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea

J Sohn

Department of Biochemistry, College of Medicine, Korea University, Seoul, Korea

G G Song

Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea; Division of Rheumatology, Department of Internal Medicine, Anam Hospital, College of Medicine, Korea University, 126-1 Ka, Anam-Dong, Seongbuk-Ku, Seoul, 136-705, Koreagsong{at}ns.kumc.co.kr

The objective of this study was to determine whether the polymorphisms of the CTLA-4 exon 1 (/49) and promoter (7318) are associated with susceptibility to systemic lupus erythematosus (SLE) and its clinical features. Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1 (/49) and promoter (7318) in 80 SLE patients and 86 healthy control subjects. The genotype distribution of the CTLA-4 exon 1 (/49) differed between SLE patients and controls (w² = 6.74, 2 degrees of freedom (d.f.), P = 0.03). The CTLA-4 AG genotype occurred more frequently in patients with SLE (46.3% vs 33.7% controls). On the other hand, the CTLA-4 AA genotype as well as the CTLA-4 GG genotype was less frequent among SLE patients than among control subjects (1.3% vs 9.3% and 52.5% vs 57.0%, respectively). The genotype distribution of the CTLA-4 promoter (-318) different between SLE patients and control subjects (CT, TT, CC; genotype 27.5%, 0%, 72.5% vs 16.3%, 4.7%, 79.1% controls respectively, w² = 6.36 2 d.f., P = 0.04). However, Fisher's exact or w² P-values for each genotypes of the CTLA-4 exon l (+49) and promoter (-318) between SLE and control group < 0.05. Clinically, in the lupus patients there was no significant difference according to the CTLA-4 polymorphism.

In conclusion, no correlation was found between CTLA-4 exon 1 (+49) and promoter (-318) polymorphisms and SLE in our study.

Key Words: systematic lupus erythematosus • CTLA-4 • polymorphisms

Lupus, Vol. 10, No. 9, 601-605 (2001)
DOI: 10.1191/096120301682430177


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C G Parks, L L Hudson, G S Cooper, M A Dooley, E L Treadwell, E W St Clair, G S Gilkeson, and J P Pandey CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States Lupus, October 1, 2004; 13(10): 784 - 791. [Abstract] [PDF]