This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Huang, C-M Articles by Tsai, F-J Search for Related Content PubMed PubMed Citation Articles by Huang, C-M Articles by Tsai, F-J Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Medline Plus Health Information Lupus Social Bookmarking                         What's this?

Association of vitamin D receptor gene BsmI polymorphisms in Chinese patients with systemic lupus erythematosus

Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical College Hospital, Taiwan

M-C Wu

J-Y Wu

F-J Tsai

Department of Medical Genetics, China Medical College Hospital, Taichung, Taiwan

The purpose of this study was to evaluate whether vitamin D receptor (VDR) genes BsmI polymorphisms were markers for susceptibility to or severity of systemic lupus erythematosus (SLE) in Chinese patients in Taiwan.

The study included 47 Chinese patients with SLE. In addition, 90 unrelated, healthy individuals living in central Taiwan served as control subjects. Each polymorphism was detected as a result of polymerase chain reaction (PCR)-based restriction analysis. A PCR product length was determined to be 580 bp (BB) whereas two fragments of 405 and 175 bp were determined to be excisable lengths (bb) by BsmI endonuclease. The relationship between Bsm polymorphisms and clinical manifestations of SLE was evaluated.

We found that BB was significantly more common and bb less common in SLE than in control group (w² 54.2, P 0.0001). In addition, the frequency of B allele was also significantly more common in patients with SLE than in the healthy control subjects (w² 38.7, P 0.0001), giving an odds ratio of 7.14 (95% confidence interval 3.53–14.4). In the SLE patients, we did not detect any associations of VDR genotype with the clinical, laboratory profiles, or lupus nephritis (w² 2.34, P 0.3).

This study indicated an increased distribution of VDR BB genotype and B allelic frequencies in the Chinese SLE patients in Taiwan. However, there were no associationsbetween the frequency of VDR allelic variations and clinical manifestations, laboratory profiles, or lupus nephritis.

Key Words: vitamin D receptor genotype • systemic lupus erythematosus

Lupus, Vol. 11, No. 1, 31-34 (2002)
DOI: 10.1191/0961203302lu143oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				Y. Arnson, H. Amital, and Y. Shoenfeld Vitamin D and autoimmunity: new aetiological and therapeutic considerations Ann Rheum Dis, September 1, 2007; 66(9): 1137 - 1142. [Abstract] [Full Text] [PDF]

				G. E. Mullin and A. Dobs Vitamin D and Its Role in Cancer and Immunity: A Prescription for Sunlight Nutr Clin Pract, June 1, 2007; 22(3): 305 - 322. [Abstract] [Full Text] [PDF]

				Y. Motohashi, S. Yamada, T. Yanagawa, T. Maruyama, R. Suzuki, M. Niino, T. Fukazawa, A. Kasuga, H. Hirose, K. Matsubara, et al. Vitamin D Receptor Gene Polymorphism Affects Onset Pattern of Type 1 Diabetes J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3137 - 3140. [Abstract] [Full Text] [PDF]