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Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations

Department of Pediatrics, University Medical Center Ljubljana, Slovenia

R Cimaz

Department of Pediatrics, Istituti Clinici di Perfezionamento, Milan, Italy

P L Meroni

IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Via L. Ariosto 13, 20145 Milan, Italy. pierluigi.meroni{at}unimi.it

In recent years, antiphospholipid antibodies (aPL) and their associated clinical features have been recognized increasingly in various pediatric autoimmune and non-autoimmunediseases. Pathogenic mechanisms involved in pediatric antiphospholipid syndrome (APS) appear to be the same as inadults. However, since pediatric patients do not have prothrombotic risk factors present in adults, there clearly are differences in the spectrum of clinical findings. The frequency of aPL-related thrombotic events is generally low in pediatric populations. On the other hand, various commonly acquired infections are likely to be responsible for higher percentage of non-pathogenic and transient aPL in childhood. Such points have to be considered in clinical judgment of elevated aPL in children. In this review we summarize the recent data on the prevalence and clinical significance of aPL in neonates, children and adolescents.

Key Words: antiphospholipid antibodies • antiphospholipid syndrome • childhood

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