Lupus

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wu, J
Right arrow Articles by Kimberly, R P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wu, J
Right arrow Articles by Kimberly, R P
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Lupus, Vol. 11, No. 1, 42-45 (2002)
DOI: 10.1191/0961203302lu145oa
© 2002 SAGE Publications

Conservation of FceRI gamma chain coding region in normals and in SLE patients

J Wu

J C Edberg

A W Gibson

Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

R P Kimberly

Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA; THT 429, 1530 3rd Avenue South, Birmingham, AL 35294-0006, USA rpk{at}uab.edu

High-frequency single nucleotide polymorphism (SNP) alleles are useful in mapping genes responsible for disease susceptibility. Functionally, Fcg receptors (FcgR) have been implicated in autoimmune disease, and the gene encoding the signaling element for several FcgR, Fc-epsilon-receptor gamma-chain (FceRIg), has several SNPs in the immunoreceptor tyrosine activation motif (ITAM) recorded in GenBank. Direct sequencing of the FceRIg coding region found potentially polymorphic sites in the 50?30 direction in control donors, which were not confirmed in the reverse direction (n 66), and further exploration of 80 SLE patients revealed no non-synonymous SNPs. One normal donor was heterozygous for a non-synonymous SNP at nt 38 which changed the fifth codon from valine (GTG) to methionine (ATG). Although the EST databases suggest candidate SNPs, insertions and deletions, these appear to be artifacts, most probably due to secondary structure. The coding region of FceRIg shows a remarkable absence of nucleotide diversity. Either as yet unidentified regulatory elements of FceRIg or other genes in the region of human chromosome 1q23 are likely to be systemic lupus erythematosus disease susceptibility and severity genes.

Key Words: gamma chain (FceRIg) • Fc receptor • systemic lupus erythematosus • single nucleotide polymorphism


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Ann. N. Y. Acad. Sci.Home page
D. MacGLASHAN JR.
IgE and Fc{epsilon}RI Regulation
Ann. N.Y. Acad. Sci., June 1, 2005; 1050(1): 73 - 88.
[Abstract] [Full Text] [PDF]