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Lupus
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Heparin and osteoporosis during pregnancy: 2002 update

G Ruiz-Irastorza

Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, UK; Service of Internal Medicine, Hospital de Cruces Bizkaia, Spain

M A Khamashta

Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK106404.2325{at}compuserve.com

G RV Hughes

Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, UK

Althoughsignificant bone mass loss is rare duringpregnancy,some situationsmay increasethe risk of symptomaticosteoporosis.Heparin may be necessaryfor a number of pregnantwomen with systemic lupus erythematosus and antiphospholipid syndrome. The osteopenic effect of heparin is low even during pregnancy, and recent data point to a more favourable profile of low-molecular-weight heparins as compared with unfractionated heparin. Lactation results in a significant increase of calcium demands and may be a higher risk period for women at risk for osteoporosis.

Key Words: heparin • low molecular weight heparin • osteoporosis • pregnancy

Lupus, Vol. 11, No. 10, 680-682 (2002)
DOI: 10.1191/0961203302lu262oa
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