| Sign In to gain access to subscriptions and/or personal tools. |
Structural considerations of autoantibodiesRenal and Hypertension Division, Univesity of Pennsylvania, Philadelphia, PA, USA.madaio{at}mail.med.upenn.edu
Hadassah University Hospital, Jerusalem, Israel The mechanisms responsible for peptide-induced immunosuppression lupus-prone BWF1 mice were determined to be mediated via recognition by T cells, although the response was peptidespecific, as some accelerated the autoimmune response. Furthermore, this was associated with suppressionof IFN-g and IL-4 in serum and increased TGF-b. Recent isolation of peptide-specific T cells should be helpful in sorting out the mechanisms responsible for these events. In separate studies, it was demonstrated that an anti-DNA antibody that enters cells is able to transport proteins linked to it, supporting the possibility that this system can be used as a therapeutic modality to modify specific cellular activities.
Key Words: immunlogic tolerance • cytokines • T cells • autoantibodies • drug delivery
Lupus, Vol. 11, No. 12,
774-775 (2002) This article has been cited by other articles:
|
|||||||||||||||
 |
|
|
 |
Sign In to gain access to subscriptions and/or personal tools.
