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Lupus
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What's this?

Clinical laboratory assays for measuring anti-dsDNA antibodies. Where are we now?

D Isenberg

Centre for Rheumatology, The Middlesex Hospital, University College London Hospitals, Tottenham Street, W1F 4NJ, London, UK

R Smeenk

Central Laboratory of Netherlands Red Cross, Amsterdam, The Netherlands

It is over 40 years since anti-dsDNA antibodies were first described in patients with lupus. A wide variety of methods for detecting these immunoglobulins have been established. In this review, we consider the utility and practical problems that the main assays present. The clinical correlations between anti-dsDNA antibodies and clinical activity in patients with lupus is discussed.

Key Words: anti-dsDNA antibodies • SLE • lupus activity

Lupus, Vol. 11, No. 12, 797-800 (2002)
DOI: 10.1191/0961203302lu300rr
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