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Transgenic models of tolerance and autoimmunity: with special reference to systemic lupus erythematosus

Centre for Rheumatology, Department of Medicine, University College London, London, UK

D A Isenberg

Centre for Rheumatology, Bloomsbury Rheumatology Unit, Department of Medicine, University College London Hospital, Arthur Stanley House, 40–50 Tottenham Street, London W1T 4NJ, UK d.isenberg{at}ucl.ac.uk

Transgenic and knockout mouse carrying rearranged antigen-receptor genes have been invaluable for the elucidation of basic mechanisms in autoimmunity and have contributed new models of human autoimmune diseases. Several examples of transgenic models expressing rearranged immunoglobulin genes have been described. These models have provided a window into the events involved in this process, allowing the development and fate of self-reactive lymphocytes to be followed in vivo. In the B cell lineage, as in T cells, self-reactive cells have been found to undergo several distinct fates in vivo: they can be physically eliminated, functionally inactivated, or they can persist unchanged or become activated. Nevertheless the precise understanding of the molecular events leading to lymphocyte deletion, anergy or activation remains a challenge.

Key Words: autoimmunity • anti-DNA antibodies • transgenic models • tolerance • pathogenicity

Lupus, Vol. 11, No. 12, 843-849 (2002)
DOI: 10.1191/0961203302lu305rr


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