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Lupus, Vol. 11, No. 12, 872-877 (2002)
DOI: 10.1191/0961203302lu309oa

Disturbances in peripheral blood B cell subpopulations in autoimmune patients

K N Potter

Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton SO16 6YD, UKkp1{at}soton.ac.uk

C I Mockridge

Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton, UK

A Rahman

Department of Rheumatology, UCL, London, UK

S Buchan

Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton, UK

T Hamblin

Department of Haematology and Oncology, Royal Bournemouth Hospital, Bournemouth, UK

B Davidson

Department of Rheumatology, Southampton University Hospitals Trust, Southampton, UK

D A Isenberg

Department of Rheumatology, UCL, London, UK

F K Stevenson

Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton, UK

A variety of cell surface markers are being used to identify B cell subpopulations in peripheral blood. Currently at least eight subpopulationshave been identified. Analyses of healthy individuals indicate that in general the various B cell subpopulations exist in relatively similar ratios in unrelated individuals. It has been demonstrated that B lymphocyte homeostasis is disturbed during infection and autoimmune disease. In this review we compare the distribution of B cell subpopulations in the peripheral blood of patients with systemic lupus erythematosus, rheumatoid arthritis and primary Sjogren's syndrome with each other, and with healthy individuals. The different autoimmune diseases have distinct changes in the B cell subpopulations. Understanding the nature of these B subpopulation signatures will potentially impact understanding the mechanisms of disease, diagnosis and therapy.

Key Words: B cell homeostasis • SLE • rheumatoid arthritis • Sjogren's syndrome


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