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Lupus, Vol. 11, No. 2, 119-123 (2002)
DOI: 10.1191/0961203302lu152cr

Reviews

Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology

Y Yazici

Hospital for Special Surgery, Weill Medical College of Cornell University; 515 East 72nd Street no. 18E, New York, NY 10021, USA,yaziciy{at}hss.edu

D Erkan

Hospital for Special Surgery, Weill Medical College of Cornell University

D M Levine

T S Parker

The Rogosin Institute, Iris & B Gerald Cantor Clinical Research Laboratory, The Rockefeller University, New York, USA

M D Lockshin

Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, USA

Protein-losing enteropathy (PLE) is a rare manifestation of systemic lupus erythematosus (SLE). We report a severe and resistant case of PLE, discuss pathophysiology and possible role of cytokines in the disease process. We also present a review of the current literature.

Key Words: protein losing enteropathy • systemic lupus erythematosus • TNF-a • literature review • intestinal permeability • pathophysiology


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