This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Alarcón, G S Search for Related Content PubMed PubMed Citation Articles by Alarcón, G S Social Bookmarking                   What's this?

Baseline characteristics of a multiethnic lupus cohort: PROFILE

Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama, USA; 615 MEB, The University of Alabama at Birmingham, Birmingham, AL 35294, USAgraciela.alarcon{at}ccc.uab.edu

G McGwin, Jr

Department of Surgery, Section of Trauma, Burns, and Critical Care, School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA

M Petri

Division of Rheumatology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA

J D Reveille

Department of Medicine, Division of Rheumatology and Clinical Immunogenetics, School of Medicine, The University of Texas–Houston Health Science Center, Texas, USA

R Ramsey-Goldman

Division of Rheumatology, Northwestern University, School of Medicine, Evanston, IL, USA

R P Kimberly

the PROFILE Study Group

Purpose: To report the baseline characteristics of a US multi-ethnic, multi-regional, multi-institution cohort of patients with systemic lupus erythematosus (SLE) and how it was constituted. Methods: Patients with SLE per American college of Rheumatology (ACR) classification criteria, 16 years of age and older, with disease of 10 years or less, of Hispanic (H), African American (AA) or Caucasian (C) ethnicity and living in the geographic catchment areas of the participating institutions (the University of Alabama at Birmingham (UAB), Johns Hopkins University (JHU), The University of Texas-Houston Health Science Center (UTH) were eligible to enter the combined cohort (PROFILE, herein). Data from the individual SLE cohorts were pooled and the PROFILE cohort characteristics examined using descriptive statistics. Variables predictive of renal damage were then examined by logistic regression.

Results: The PROFILE cohort constituted by 568 patients (H = 78, AA = 216, C = 260 (13 other ethnicities)) is predominantly female. Non-C had a greater number of ACR criteria, and of renal involvement. Among the two non-C groups, a higher proportion of H patients have developed overall renal damage, as well as decreased glomerular filtration rate. Other than Hispanic ethnicity (odds ratio, OR = 6.27, confidence limits, CL = 1.96–220.01), sustained hypertension (OR = 14.16, CL = 4.52–4.43) was a significant predictor of renal damage, whereas belonging to the JHU cohort was protective (OR = 0.18, CL = 0.05–0.63).

Conclusions: We have constituted a large US multi-ethnic SLE cohort. Renal involvement was found to be more frequent among the non-C; within them, the H patients seem to be at higher risk for the occurrence of renal damage.

Key Words: lupus renal damage • Hispanic • African-American • ethnicity • cohort study

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. C. Edberg, J. Wu, C. D. Langefeld, E. E. Brown, M. C. Marion, G. McGwin Jr, M. Petri, R. Ramsey-Goldman, J. D. Reveille, S. G. Frank, et al. Genetic variation in the CRP promoter: association with systemic lupus erythematosus Hum. Mol. Genet., April 15, 2008; 17(8): 1147 - 1155. [Abstract] [Full Text] [PDF]

				R Ramsey-Goldman, G. Alarcon, G McGwin, M Petri, L. Vila, J. Edberg, J. Reveille, and R. Kimberly for the PR Time to seizure occurrence and damage in PROFILE, a multi-ethnic systemic lupus erythematosus cohort Lupus, March 1, 2008; 17(3): 177 - 184. [Abstract] [PDF]

				H. M. Bastian, G. S. Alarcon, J. M. Roseman, G. McGwin Jr, L. M. Vila, B. J. Fessler, J. D. Reveille, and for the LUMINA study group Systemic lupus erythematosus in a multiethnic US cohort (LUMINA) XL II: factors predictive of new or worsening proteinuria Rheumatology, April 1, 2007; 46(4): 683 - 689. [Abstract] [Full Text] [PDF]

				R T Naismith, K Trinkaus, and A H Cross Phenotype and prognosis in African-Americans with multiple sclerosis: a retrospective chart review Multiple Sclerosis, November 1, 2006; 12(6): 775 - 781. [Abstract] [PDF]

				G Contreras, V Pardo, C Cely, E Borja, A Hurtado, C De La Cuesta, K Iqbal, O Lenz, A Asif, N Nahar, et al. Factors associated with poor outcomes in patients with lupus nephritis Lupus, November 1, 2005; 14(11): 890 - 895. [Abstract] [PDF]

				G Contreras, E Tozman, N. Nahar, and D. Metz Maintenance therapies for proliferative lupus nephritis: mycophenolate mofetil, azathioprine and intravenous cyclophosphamide Lupus, March 1, 2005; 14(3_suppl): s33 - s38. [Abstract] [PDF]

				C.-S. Yee, C. Gordon, A. C. Gelber, L. Christopher-Stine, D. M. Fine, Y. Farhey, E. Hess, G. Contreras, O. Lenz, and D. Roth Sequential Therapies for Proliferative Lupus Nephritis N. Engl. J. Med., June 10, 2004; 350(24): 2518 - 2520. [Full Text] [PDF]

				G. Contreras, V. Pardo, B. Leclercq, O. Lenz, E. Tozman, P. O'Nan, and D. Roth Sequential Therapies for Proliferative Lupus Nephritis N. Engl. J. Med., March 4, 2004; 350(10): 971 - 980. [Abstract] [Full Text] [PDF]

				G. S. Alarcon, J. M. Roseman, G. McGwin Jr, A. Uribe, H. M. Bastian, B. J. Fessler, B. A. Baethge, A. W. Friedman, and J. D. Reveille Systemic lupus erythematosus in three ethnic groups. XX. Damage as a predictor of further damage Rheumatology, February 1, 2004; 43(2): 202 - 205. [Abstract] [Full Text] [PDF]

				M L Sanchez, G S Alarcon, G McGwin Jr, B J Fessler, and R P Kimberly Can the weighted criteria improve our ability to capture a larger number of lupus patients into observational and interventional studies? A comparison with the American College of Rheumatology Criteria Lupus, June 1, 2003; 12(6): 468 - 470. [Abstract] [PDF]

				J Calvo-Alen, J D Reveille, V Rodriguez-Valverde, G McGwin Jr, B A Baethge, A W Friedman, and G S Alarcon Clinical, immunogenetic and outcome features of Hispanic systemic lupus erythematosus patients of different ethnic ancestry Lupus, May 1, 2003; 12(5): 377 - 385. [Abstract] [PDF]