SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Lupus
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Simón, J A
Right arrow Articles by Varela, J A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Simón, J A
Right arrow Articles by Varela, J A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Clinical and immunogenetic characterization of Mexican patients with ‘Rhupus’

J A Simón

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México DF, México

J Granados

J Cabiedes

J Rúz Morales

J Alcocer Varela

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México DF, México

The coexistence of systemic lupus erythematosus and rheumatoid arthritis (rhupus), is a rare clinical condition. To date, 50 cases of rhupus have been described worldwide; however, the lack of clinical criteria for this rheumatic condition has created confusion in the characterization of this disorder. Nevertheless, in this paper we describe a comprehensive clinical and serological characterization of a cohort of 22 Mexican patients with rhupus, supported by generic HLA-DR phenotyping.

We found that rhupus patients have a special clinical behavior. In this setting, the signs and symptoms of rheumatoid arthritis prevail, little organic damage associated with systemic lupus erythematosus (SLE) exists and none of the cases present thrombosis or morbidity during pregnancy in spite of presenting a high frequency of anticardiolipin antibodies. We also found an increased frequency of HLA-DR1 and HLA-DR2 alleles compared to healthy ethnically matched controls, systemic lupus erythematosus and rheumatoid arthritis patients.

Key Words: rhupus • systemic lupus erythematosus • rheumatoid arthritis • coexistence

Lupus, Vol. 11, No. 5, 287-292 (2002)
DOI: 10.1191/0961203302lu189oa
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 The Journal of RheumatologyHome page
M. ICEN, P. J. NICOLA, H. MARADIT-KREMERS, C. S. CROWSON, T. M. THERNEAU, E. L. MATTESON, and S. E. GABRIEL
Systemic Lupus Erythematosus Features in Rheumatoid Arthritis and Their Effect on Overall Mortality
J Rheumatol, January 1, 2009; 36(1): 50 - 57.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
G. Damian-Abrego, J Cabiedes, and A. Cabral
Anti-citrullinated peptide antibodies in lupus patients with or without deforming arthropathy
Lupus, April 1, 2008; 17(4): 300 - 304.
[Abstract] [PDF]

Home page
 NEJMHome page
L. Dagna, G. Frontino, L. Praderio, E. F. Remmers, R. M. Plenge, and P. K. Gregersen
Rheumatoid Arthritis, Systemic Lupus Erythematosus, and STAT4
N. Engl. J. Med., December 13, 2007; 357(24): 2517 - 2518.
[Full Text] [PDF]


Advertisement