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Allergic disorders in systemic lupus erythematosus: prevalence and family history

Department of Medicine, Juntendo University Izu-Nagaoka Hospital, 1129 Nagaoka, Izu-Nagaoka-cho, Tagata-gun, Shizuoka 410-2295, Japan. sekigawa{at}mtd.biglobe.ne.jp

T Yoshiike

Department of Dermatology, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan

N Iida

Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan

H Hashimoto

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

H Ogawa

Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan

The relationship between allergic disorders (such as atopic dermatitis, asthma, allergic rhinitis and allergic conjunctivitis) and systemic lupus erythematosus (SLE) is still unclear and controversial. We investigated the prevalence of these allergic disorders in SLE patients and their families. A questionnaire about the history of allergy was completed by 52 SLE patients and by 52 matched (including race, age, sex and region) non-SLE controls. Our results indicated that there was a signi" cantly lower incidence of these allergic diseases in SLE patients, especially those who had an allergic family histories, when compared with the controls. These " ndings may be related to the immunological similarities and differences between SLE and various allergic diseases.

Key Words: allergic disease • CD4=CD8 ratio • IgE • systemic lupus erythematosus

Lupus, Vol. 11, No. 7, 426-429 (2002)
DOI: 10.1191/0961203302lu221oa


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