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Lupus
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Aseptic meningo-encephalitis related to dexibuprofen use in a patient with systemic lupus erythematosus: a case report with MR findings

G Obermoser

Department of Dermatology, University Hospital of Innsbruck,Anichstrasse 35, 6020Innsbruck,Austriagerlinde.obermoser{at}uibk.ac.at

R Bellmann

Department of Internal Medicine, University Hospital, Innsbruck, Austria

B Pfausler

E Schmutzhard

Department of Neurology, University Hospital, Innsbruck, Austria

N Sepp

Department of Dermatology, University Hospital Innsbruck, Austria

We report of a 22-year-old woman with systemic lupus erythematosus (SLE) who was admitted to the intensive care unit (ICU) because of obtundation and a febrile illness. These symptoms had occurred after ingestion of 16 tablets of dexibuprofen.Cerebral magnetic resonance imaging (MRI) disclosed multiple hyperintense white matter abnormalities without gadolinium enhancement. No infectious origin or signs of a lupus flare were found.

Our report is the first description of MR findings in dexibuprofen-induced aseptic meningitis, which here is actually a case of meningo-encephalitis. Patients suffering from SLE show increased susceptibility to non steroidal anti-inflammatory drug (NSAID)-induced aseptic meningitis/encephalitis, an important differential diagnosis to be considered at the work-up of altered mental status.

Key Words: aseptic meningo-encephalitis • cerebral MRI • dexibuprofen • NSAID • systemic lupus erythematosus

Lupus, Vol. 11, No. 7, 451-453 (2002)
DOI: 10.1191/0961203302lu218cr
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