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Lupus
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The immune development in a child born to a cyclosporin A-treated woman with systemic lupus erythematosus/polymyositis

P Airó

Division of Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy; Servizio di Reumatologia ed Immunologia Clinica, Spedali Civili, Piazzale Spedali Civili, I-25124 Brescia, Italycattaneo{at}master.cci.unibs.it

C M Antonioli

Division of Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy

M Motta

Division of Gynecology and Obstetrics, Spedali Civili, Brescia, Italy

D Faden

Division of Neonatology, Spedali Civili, Brescia, Italy

G Chirico

Division of Gynecology and Obstetrics, Spedali Civili, Brescia, Italy

R Cattaneo

A Tincani

Division of Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy

The case of a woman affected by an overlap syndrome systemic lupus erythematosus/polymyositis (PM), who presented with active myositis at the start of the pregnancy, is reported. Therapy with cyclosporin, corticosteroids, hydroxychloroquine and high-dose intravenous immunoglobulin induced a progressive remission of clinical and laboratory signs of myositis. At 33 weeks of gestation, after a premature pre-term rupture of membrane, a male child was delivered. Although premature, and small for gestational age, he had a normal growth, and did not show any clinical sign suggestive of immune deficiency. Lymphocyte phenotypical and functional studies, as well as response to vaccination, were also normal.

Key Words: cyclosporin • newborn • polymyositis • pregnancy • SLE

Lupus, Vol. 11, No. 7, 454-457 (2002)
DOI: 10.1191/0961203302lu222cr
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This article has been cited by other articles:


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