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Characterization of CD3+CD4-CD8- (double negative) T cells in patients with systemic lupus erythematosus: production of IL-4

Department of Immunology and Molecular Pathology, Royal Free and University College School of Medicine, London, UK; Division of Rheumatology, Department of Medicine, Royal Free and University College School of Medicine, London, UK

A Anand

A Blofeld

Department of Immunology and Molecular Pathology, Royal Free and University College School of Medicine, London, UK

D A Isenberg

Division of Rheumatology, Department of Medicine, Royal Free and University College School of Medicine, London, UK

P M Lydyard

Department of Immunology and Molecular Pathology, Royal Free and University College School of Medicine, London, UK; Department of Immunology and Molecular Pathology, Royal Free and University College School of Medicine, Windeyer Research Institute, 46 Cleveland St, London W1T 4JF, UKp.lydyard{at}ucl.ac.uk

Systemic lupus erythematosus (SLE) is a chronic autoimmune rheumatic disease that may affect every organ or system in the body. We have shown previously that the TCR ab subpopulation of CD3CD4⁷CD8⁷, DN T cells is expanded in patients with SLE and that double negative T cells express increased levels of activation markers compared both with healthy people and with patients with rheumatoid arthritis, (RA) as autoimmune controls. The aim of this study was to characterize these cells in terms of their ability to produce IL4, a Th2 cytokine, both spontaneously and after mitogen stimulation. It was found that a higher percentageof TCR ab double negative T cells from patients with SLE contained IL4 constitutively than did the same population of cells from healthy people or from those with RA. After mitogen stimulation, there was no signi" cant difference in the amount of IL4 produced by each of the three groups. Further study of patients producing high levels of IL4 (about one third of the patients) indicated that they had a lower percentageof abT cells in the double negative compartment than did patients with fewer IL4 containing cells.

Key Words: double negative • IL4 • SLE • T cells

Lupus, Vol. 11, No. 8, 501-507 (2002)
DOI: 10.1191/0961203302lu234oa


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