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Prevalence of T cell receptor chain deficiency in systemic lupus erythematosus

Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, and Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

J P Mitchell

Rheumatology Service, Walter Reed Army Medical Center, Washington, DC, USA

R P Ceruti

Rheumatology Service, Walter Reed Army Medical Center, Washington, DC, USA

M A Malloy

Rheumatology Service, Walter Reed Army Medical Center, Washington, DC, USA

G C Tsokos

Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, and Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA, gtsokos{at}usuhs.mil

T cells from patients with systemic lupus erythematosus (SLE) display antigen receptor-mediated signaling aberrations associated with defective T cell receptor (TCR) z chain expression. We determined the prevalence of TCR z chain deficiency in SLE from a large cohort of unselected racially diverse patients with different levels of clinical disease activity as determined by SLE Disease Activity Index (SLEDAI). Our data show that the occurrence of TCR z chain deficiency is 78% in SLE patients. There was no relationship between the deficiency of TCR z chain and the SLEDAI scores or therapy. TCR z chain deficiency was also not associated with age, race or gender and persisted over a 3 year follow-up period. Thus, there is a high prevalence of TCR z chain deficiency in SLE patients that is independent of disease activity, and persists over time indicating an important role for TCR z chain deficiency in SLE pathogenesis.

Key Words: human T lymphocytes • lupus • signal transduction • SLEDAI • TCR chain

Lupus, Vol. 12, No. 1, 46-51 (2003)
DOI: 10.1191/0961203303lu281oa


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