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Lupus
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Bullous SLE: response to methotrexate and relationship with disease activity

G Malcangi

Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Torrette di Ancona, Italy

G Brandozzi

Divisione di Dermatologia, Torrette di Ancona, Italy

M Giangiacomi

Istituto di Anatomia Patologica dell’Universitàdegli Studi di Ancona, Torrette di Ancona, Italy

M Zampetti

Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Torrette di Ancona, Italy

M G Danieli

Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Torrette di Ancona, Italy, eleonora{at}popcsi.unian.it

We report on a case of 40-year-old female with systemic lupus erythematosus (SLE) who developed a severe bullous eruption on sun-exposed areas. The bullous manifestation was associated with a flare of lupus serologies, whereas the previous manifestations of the disease were quiescent. Due to prior intolerance to many drugs, she was given oral methotrexate (10 mg=week). The drug administration was followed by a rapid and full resolution of cutaneous lesions. Five months later she developed a class III lupus nephritis. Our case is the first report of efficacy of methotrexate in bullous SLE and rises the question of the relationship between bullous eruption and SLE activity.

Key Words: systemic lupus erythematosus • bullous manifestation • skin • methotrexate

Lupus, Vol. 12, No. 1, 63-66 (2003)
DOI: 10.1191/0961203303lu241cr
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