This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Tsai, M-H Articles by Liou, L-b Search for Related Content PubMed PubMed Citation Articles by Tsai, M-H Articles by Liou, L-b Social Bookmarking                         What's this?

Anticardiolipin antibodies in various diseases in Taiwan: a retrospective analysis

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan County, Taiwan

W-P Tsai

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan County, Taiwan

S-T Liao

Division of Rheumatology and Immunology, Department of Internal Medicine, Taipei Municipal Jen-Ai Hospital, Taipei city, Taiwan

L-b Liou

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan County, Taiwan, b890121{at}adm.cgmh.org.tw

The goals of this study are to determine the frequency of anticardiolipinantibodies (ACA) in patients with various diseases and to evaluate the clinical significance of ACA in Taiwan. We collected 690 patients from ACA laboratory records. They were divided into eight groups in order to compare ACA percentages. Positive rates of ACA in different disease groups were below 20%, except for 38.2% in autoimmune diseases with vascular thrombosis. Compared with old stroke, the ACA positivity in young stroke was not significantly different (P 0.482). The positive percentage of lupus anticoagulant (LA) (2.86%) was lower than that of ACA (15.66%) in young stroke (P 0.015). Among patients with pregnancy loss or prematurity, the ACA positivity in lupus patients (44.44%) was higher than without lupus (9.76%; P 0.01). The prevalence of ACA is higher in patients with vascular thrombosis complicated by autoimmune diseases than with thrombosis alone in Taiwan. Young and old stroke do not differ in ACA positivity. Moreover, ACA is more prevalent than LA for young stroke related coagulation.The ACA positivity for pregnancy loss or prematurity is very low in Taiwan. In summary, this is the first report on the frequency of ACA and other coagulation factors in various diseases in Taiwan.

Key Words: anticardiolipin antibodies • autoimmune diseases • pregnancy loss • stroke • vascular thrombosis

Lupus, Vol. 12, No. 10, 747-753 (2003)
DOI: 10.1191/0961203303lu459oa


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				H. S. Chen, W. P. Tsai, H. S. Leu, H. H. Ho, and L. B. Liou Invasive fungal infection in systemic lupus erythematosus: an analysis of 15 cases and a literature review Rheumatology, March 1, 2007; 46(3): 539 - 544. [Abstract] [Full Text] [PDF]

				W. H. Chen, Y.-F. Kao, M.-Y. Lan, Y.-Y. Chang, S.-S. Chen, and J.-S. Liu The Increase of Blood Anticardiolipin Antibody Depends on the Underlying Etiology in Cerebral Ischemia Clinical and Applied Thrombosis/Hemostasis, January 1, 2006; 12(1): 69 - 76. [Abstract] [PDF]

				W. H. Chen, Y.-F. Kao, M.-Y. Lan, Y.-Y. Chang, S.-S. Chen, and J.-S. Liu The Increase of Blood Anticardiolipin Antibody Depends on the Underlying Etiology in Cerebral Ischemia Clinical and Applied Thrombosis/Hemostasis, April 1, 2005; 11(2): 203 - 210. [Abstract] [PDF]