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Anticardiolipin antibodies in various diseases in Taiwan: a retrospective analysis

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan County, Taiwan

W-P Tsai

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan County, Taiwan

S-T Liao

Division of Rheumatology and Immunology, Department of Internal Medicine, Taipei Municipal Jen-Ai Hospital, Taipei city, Taiwan

L-b Liou

Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan County, Taiwan, b890121{at}adm.cgmh.org.tw

The goals of this study are to determine the frequency of anticardiolipinantibodies (ACA) in patients with various diseases and to evaluate the clinical significance of ACA in Taiwan. We collected 690 patients from ACA laboratory records. They were divided into eight groups in order to compare ACA percentages. Positive rates of ACA in different disease groups were below 20%, except for 38.2% in autoimmune diseases with vascular thrombosis. Compared with old stroke, the ACA positivity in young stroke was not significantly different (P 0.482). The positive percentage of lupus anticoagulant (LA) (2.86%) was lower than that of ACA (15.66%) in young stroke (P 0.015). Among patients with pregnancy loss or prematurity, the ACA positivity in lupus patients (44.44%) was higher than without lupus (9.76%; P 0.01). The prevalence of ACA is higher in patients with vascular thrombosis complicated by autoimmune diseases than with thrombosis alone in Taiwan. Young and old stroke do not differ in ACA positivity. Moreover, ACA is more prevalent than LA for young stroke related coagulation.The ACA positivity for pregnancy loss or prematurity is very low in Taiwan. In summary, this is the first report on the frequency of ACA and other coagulation factors in various diseases in Taiwan.

Key Words: anticardiolipin antibodies • autoimmune diseases • pregnancy loss • stroke • vascular thrombosis

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