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Renal involvement in primary antiphospholipid syndrome and its response to immunosuppressive therapy

Division of Rheumatology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey, ckorkmaz{at}ogu.edu.tr

S Kabukcuoglu

Department of Pathology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

S Isiksoy

Department of Pathology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

A U Yalçin

Dvision of Nephrology, Department of Internal Medicine, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

Antiphospholipid syndrome (APS) is the association between antiphospholipid antibodies, venous and arterial thrombosis and pregnancy morbidity. Although the kidney may be affected in APS, the treatment of renal involvement is yet to be elucidated.This report describes the clinical and laboratory features of four patients with primary APS nephropathy, and the beneficial effect of immunosuppressive therapy accompanied by warfarin and angiotensin-convertingenzyme inhibitor. We also briefly discuss the possible mechanisms of the beneficial effects of immunosuppressiveson primary APS nephropathy.

Key Words: antiphospholipidantibodies • antiphospholipidsyndrome • immunosuppressivetreatment • renal involvement

Lupus, Vol. 12, No. 10, 760-765 (2003)
DOI: 10.1191/0961203303lu461oa


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