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Coexistence of lupus anticoagulant and acquired haemophilia in a patient with monoclonal gammopathy of unknown significance

Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

R Abiad

Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon

I Uthman

Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, iuthman{at}aub.edu.lb

Acquired haemophilia or factor VIII (FVIII) deficiency, caused by FVIII inhibitorantibodies, is a very rare condition that commonly results in severe haemorrhagic complications. We report a case of acquired haemophilia presenting with a left calf nontraumatichaematoma. The patient was also found to have lupus anticoagulant (LAC). The simultaneous presence of LAC and FVIII inhibitor is exceedingly rare. The differentiationbetween these two conditions is crucial, because both result in a prolongationof the activated partial thromboplastintime test, which does not correct when mixed with the plasma of a normal control; however, the clinical manifestations range from thrombosis in the presence of LAC to massive haemorrhage with FVIII inhibitors.

Key Words: acquired haemophila • factor VIII inhibitors • lupus anticoagulant • monoclonal gammopathy

Lupus, Vol. 12, No. 11, 854-856 (2003)
DOI: 10.1191/0961203303lu463cr


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