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Lupus
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Quantitative magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus

P L Peterson

Lupus Research Unit, St Thomas’ Hospital, London, UK, ppeterson{at}doctors.org.uk

F A Howe

CRC Biomedical Magnetic Research Group, St George’s Hospital Medical School, London, UK

C A Clark

CRC Biomedical Magnetic Research Group, St George’s Hospital Medical School, London, UK

J S Axford

Academic Unit for Musculoskeletal Disease, St George’s Hospital Medical School, Cranmer Terrace, London, UK

Neuropsychiatric symptoms are common in systemic lupus erythematosus (SLE) but are poorly understood.Although there is a wide spectrum of clinical manifestations, brain histologyoften simply shows a bland vasculopathy. Magnetic resonance techniques such as magnetic resonance spectroscopy, magnetization transfer imaging and diffusion weighted imaging have been used to try to improve our understandingof the pathophysiologicalmechanisms involved in neuropsychiatric lupus (NPSLE). This article reviews the current literature on the use of these techniques and their possible future role as diagnostic tools in NPSLE.

Key Words: lupus • MRI • MR spectroscopy (or MRS) • neuropsychiatric • SLE

Lupus, Vol. 12, No. 12, 897-902 (2003)
DOI: 10.1191/0961203303lu499oa
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