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Lupus, Vol. 12, No. 2, 117-123 (2003)
DOI: 10.1191/0961203303lu322oa

Detection and clinical significance of Ba2+- and Sr2+-dependent antiprothrombin antibodies in patients with systemic lupus erythematosus and antiphospholipid syndrome

T Sanaka

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan

J Matsuda

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan, jmatsuda{at}med.teikyo-u.ac.jp

T Teramoto

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan

We conducted this study to confirm whether or not Ca2+-dependent antiprothrombinantibody (aPT) in patients’sera with systemic lupuserythematosusand=or primary antiphospholipidsyndromewould react to prothrombin=phosphatidylserinein the presenceof Sr2+, Mn2+ or Ba2+, or divalentmetal ions like Ca2+, utilizingELISA, and to analyze the clinical significance of these metal-dependentaPT. We found the presence of Ba2+- and Sr2+-dependent IgG, IgM and IgA-aPT in up to 65% of patients negative for Ca2+-dependent IgG-, IgM and IgA-aPT. Maximally 69% of them were complicated by antiphospholipidsyndrome-relatedsymptoms. These data suggest that the measurementof Ba2+- and Sr2+- along with Ca2+-dependentaPT may become a clinicallyuseful tool to correctly detect patients with antiphospholipid-related complications. However, further study is needed to clarify the clinicopathologicaldifferences among these aPTs in the future.

Key Words: antiphospholipid antibody • antiprothrombin antibody • lupus anticoagulant • anticardiolipin antibody


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