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Lupus, Vol. 12, No. 2, 136-139 (2003)
DOI: 10.1191/0961203303lu258cr

Pancreatitis leading to thrombotic thrombocytopenic purpura in systemic lupus erythematosus: a case report and review of literature

R Singh

Department of Medicine, LSU Health Sciences Center, New Orleans, Louisiana, USA

B Saunders

Department of Medicine, LSU Health Sciences Center, New Orleans, Louisiana, USA

E Scopelitis

Department of Medicine, LSU Health Sciences Center, New Orleans, Louisiana, USA

Pancreatitis is a well-establishedbut unusual complicationof thrombotic thrombocytopenicpurpura (TTP). It is also an unusual complication of systemic lupus erythematosus (SLE). However, TTP occurring as a consequence of acute pancreatitis in a patient with SLE has never been reported. We report a 24-year-old African American woman with active systemic lupus (SLE) who developed thrombotic thrombocytopenic purpura (TTP) following an episode of acute pancreatitis. The TTP was manifested by low-grade fever, microangiopathic hemolytic anemia, renal insufficiency, altered mental status, seizures and thrombocytopenia. The patient was initially treated with pulse corticosteroids with inadequate response and subsequentlywith daily plasmaphresis, leading to full remission. This case represents first report of pancreatitis leading to TTP in a patient with systemic lupus erythematosus.

Key Words: acute pancreatitis • systemic lupus erythematosus • thrombotic thrombocytopenic purpura


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